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Reduction of smoking urges with intranasal insulin: a randomized, crossover, placebo-controlled clinical trial

Body Composition Assessment
Hamidovic A et al.
Used Parameters : BMI

Publication Year : 2017

Country : USA

Journal : Molecular Psychiatry

Many cigarette smokers express a desire to quit smoking, but~ 85% of cessation attempts fail. In our attempt to delineate genetic modulators of smoking persistence, we have earlier shown that a locus within an~ 250 kb haplotype block spanning the 5'untranslated region region of insulin-degrading enzyme is associated with serum cotinine levels; the study's measure of smoking quantity. Based on our findings, and coupled with recent preclinical studies showing the importance of multiple neuropeptides in reinstatement of drug use, we …
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