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Dynamics of L-carnitine in plasma and urine in patients undergoing cisplatin chemotherapy

Cancer/ Palliative treatment
Gomi D et al.
Used Parameters : SMM

Publication Year : 2017

Country : Japan

Journal : Chemotherapy

Background and Aims: Several studies have indicated that cisplatin (cis-diamminedichloroplatinum II; CDDP) causes urinary excretion of L-carnitine (LC). However, the underlying cofactors affecting the increased urinary excretion remain unclear. The present study was performed to evaluate the dynamics of LC in plasma and urine after CDDP chemotherapy and to examine the relations with clinical parameters, such as gender, body mass index (BMI), and renal function. Methods: Twenty-two patients treated with CDDP …
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