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Repeated combined chemotherapy with cisplatin lowers carnitine levels in gastric cancer patients

Cancer/ Palliative treatment
A Kawai et al.
Used Parameters : BMI, SMM, PBF, VFA

Publication Year : 2017

Country : Japan

Journal : Annals of Nutrition and Metabolism

Background/Aims: Carnitine plays an important role in the metabolism of fatty acids. It has also been reported that the administration of anticancer drugs may lead to reductions in serum carnitine levels due to decreased activity of organic cation transporter novel 2, which plays a role in the reabsorption of carnitine in the tubules of the kidney. We therefore studied the change in carnitine levels when chemotherapy was administered repeatedly to patients with gastric cancer. Methods: Ten patients with upper gastrointestinal cancer were enrolled …
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