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Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and β-cell

Body Composition Assessment
Lacombe et al.
Used Parameters : BMI

Publication Year : 2020

Country : Canada

Journal : Am J Physiol Endocrinol Metab

Osteocalcin (OCN) is a bone-derived hormone involved in the regulation of glucose metabolism. In serum, OCN exists in carboxylated and uncarboxylated forms (ucOCN), and studies in rodents suggest that ucOCN is the bioactive form of this hormone. Whether this is also the case in humans is unclear, because a reliable assay to measure ucOCN is not available. Here, we established and validated a new immunoassay (ELISA) measuring human ucOCN and used it to determine the level of bioactive OCN in two cohorts of …
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