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The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

Body Composition Assessment
Author
Ewout J Hoorn et al.
Used Parameters : Not mentioned

Publication Year : 2011

Country : USA

Journal : Nature Medicine

Calcineurin inhibitors (CNIs) are immunosuppressive drugs that are used widely to prevent rejection of transplanted organs and to treat autoimmune disease. Hypertension and renal tubule dysfunction, including hyperkalemia, hypercalciuria and acidosis, often complicate their use 1, 2. These side effects resemble familial hyperkalemic hypertension, a genetic disease characterized by overactivity of the renal sodium chloride cotransporter (NCC) and caused by mutations in genes encoding WNK kinases. We hypothesized that CNIs induce …
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