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Pharmacokinetics of tacrolimus according to body composition in recipients of kidney transplants

Nephrology
Author
Seung Seok Han
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Used Parameters : FFM, BFM

Publication Year : 2012

Country : Korea

Journal : Kidney Research and Clinical Practice

Background Currently, the dosage of tacrolimus used after transplantation is based on the patient's body weight. However, there is a low correlation between body weight and body composition in kidney transplant recipients. In this study, we evaluate the pharmacokinetics of tacrolimus according to body composition in 18 Korean kidney transplant recipients with stable graft function. Methods Body composition parameters were calculated using bioelectrical impedance analysis. Pharmacokinetic profiles were determined 0, 1, 2, 3, and 4 …
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