Introduction L-Carnitine is a substance produced from endogenous synthesis and dietary sources. This amino acid has antioxidant properties by reducing the effects of oxidative stress. The purpose of this study was to investigate the effects of L-carnitine supplementation on oxidative and metabolic status in patients with Type 2 diabetes mellitus (T2DM). Method This was a randomized, double-blind, placebo-controlled clinical trial performed on seventy patients with T2DM. The participants were randomly assigned to an L-carnitine group (LG) …

Purpose We compared the effect of diets with different amounts and sources of dietary protein on insulin sensitivity (IS) in subjects with obesity and insulin resistance (IR). Methods Eighty subjects with obesity (BMI≥ 30 kg/m 2) and IR (Matsuda index< 4.3 and HOMA-IR≥ 2.5) over 18 years old were randomized to four groups for a one-month period: a normal protein diet (< 20%) with a predominance of animal protein (Animal NP) or vegetable protein (Vegetable NP) and a high-protein diet (25–30%) with a predominance of animal protein …

Abstract Aims/Introduction The present study aimed to clarify the prevalence and clinical characteristics of sarcopenia and dynapenia, which are muscle weakness with and without low muscle mass, respectively, in Japanese patients with type 1 diabetes mellitus and type 2 diabetes mellitus. Materials and Methods This cross‐sectional study enrolled 1,328 participants with type 1 diabetes (n= 177), type 2 diabetes (n= 645) and without diabetes (n= 506). Sarcopenia was defined as a low grip strength and slow gait speed with low skeletal …

Objective Although a number of studies have shown that both short and long sleep durations were associated with the risk of metabolic disorders related to obesity, the underlying mechanism is still not fully understood. In this study, we analyzed the association of sleep duration with metabolic, anthropometric, and lifestyle factors in patients with type 2 diabetes. Methods The subjects were 279 patients with type 2 diabetes 63 (52-70) years old (median and interquartile range) with a body mass index of 25.0 (22.2-28.3) kg/m 2 and HbA1c levels …

Exercise has been reported to be effective in maintaining and recovering muscle; however, the effect of exercise combined with adequate or inadequate protein intake on muscle mass is not clear. Therefore, this study investigates the effect of exercise habit on changes in muscle mass, with adequate or inadequate protein intake. This retrospective cohort study included 214 elderly patients with type 2 diabetes. The rate of skeletal muscle mass index (SMI) change (%) was defined as ((SMI at follow-up minus SMI at baseline)/(follow-up years …

Numerous studies have identified the various fat mass and obesity-associated (FTO) genetic variants associated with obesity and its metabolic consequences; however, the impact of dietary factors on these associations remains unclear. The aim of this study was to evaluate the association between FTO single nucleotide polymorphisms (SNPs), daily macronutrient intake, and obesity and its metabolic consequences. From 1549 Caucasian subjects of Polish origin, genotyped for the FTO SNPs (rs3751812, rs8044769, rs8050136, and …

Vitamin D deficiency may play an important role in obesity. The aim of the study was to explore the relationship between vitamin D status and visceral fat accumulation in males with type 2 diabetes. A cross-sectional study was conducted on 128 adult males with type 2 diabetes in Qinhuangdao. The nutritional status of vitamin D was assessed by circulating levels of 25 (OH) D, vitamin D deficiency, 30 nmol/L, vitamin D insufficiency 30–50 nmol/L and vitamin D sufficiency. 50 nmol/L. Accumulation of visceral fat was defined as visceral fat …

Background and aim Fat reduction and body contouring have become popular procedures in the cosmetic surgery industry over the past decade. There have been studies to replace invasive methods such as liposuction, with safer non-invasive procedures. We aimed to evaluate the effect of a non-invasive combination therapy of ultrasound cavitation and cryolipolysis on abdominal adipose tissue. Methods This pilot interventional study comprised 90 female individuals aged 18-65-years-old who were recruited into one of three …

Sarcopenia is considered to be a new complication of type 2 diabetes (T2DM) leading to increased risk of adverse outcome. We performed a survey to evaluate glucose metabolism and nutritional status in sarcopenia patients with T2DM. Diabetic participants aged≥ 50 years were grouped into a probable sarcopenia group with low muscle strength () and a nonsarcopenia group with normal muscle strength () according to the revised recommendations from EWGSOP2 (2018). Compared to the controls, the probable …

Background/objective: This study aimed to investigate the impacts of a 12-week training of the aerobic exercise (AE), resistance exercise (RE), and combined exercise (CE) on the serum levels of nesfatin-1, irisin-1 and some other metabolic and anthropometric indices in overweight women with metabolic syndrome. Methods: Sixty overweight women with metabolic syndrome were assigned equally into four groups: aerobic exercise (AE, n= 15), resistance exercise (RE, n= 15), combined exercise (CE, n= 15), and control (n= 15). All …