Obesity and metabolic syndrome is a worldwide pandemic and associated with high cardiovascular risk. Metabolic endotoxemia (ME) is thought to be an underlying molecular mechanism. It triggers toll-like receptor 4-mediated inflammatory adipokines and causes a chronic low grade inflammatory status, which results in cardiovascular risk increase. Exercise is the best nonpharmacological treatment to improve prognosis. In this study, we examined the circulating endotoxin level in Korean obese women and investigated effects of …

Background and objective Skeletal muscle has been suggested as an important factor in the pathophysiology of metabolic syndrome. During the aging process, muscle mass is lost in specific body parts. However, few studies have investigated the relationship between site-specific muscle loss assessed using computed tomography (CT) and metabolic syndrome. This study was conducted to investigate the association between metabolic syndrome and rectus abdominis muscle thickness at the umbilicus level (RAM), which reflects site-specific …

Aims/hypothesis Asians have a propensity to develop type 2 diabetes with a lower BMI than Western populations. This discrepancy may be due to differences in body fat and muscle mass for a given BMI. However, unlike adiposity, it is unclear whether muscle mass affects the risk of type 2 diabetes in Asian populations. Methods We conducted a 2-yearly prospective assessment of 6895 participants who were free of diabetes at the baseline examination as part of the Korean Genome Epidemiology Study. The muscle mass index …

BACKGROUND: Several cross-sectional studies have reported that thyroid hormone levels are associated with cardiovascular risk markers and metabolic syndrome (MetS) even in euthyroid subjects. However, the prognostic role of serum thyroid hormone levels in the risk of incident MetS has not been elucidated. AIM: We aimed to investigate the associations of baseline serum thyroid hormone levels with the development of MetS in healthy subjects. METHODS: This 6-year, cross-sectional, longitudinal and follow-up study was conducted in …

Objectives The aim of the study was to assess the effect of continuous and intermittent exercise in hypoxia on glycaemic control and selected markers of vascular function in patients with Type 1 diabetes (T1D). Methods 12 patients suffering from T1D for 12.1±6.0 years and 12 healthy adults performed: continuous exercise (ExC) and intermittent exercise (ExInt) in normoxia and hypoxia (FiO₂= 15.1%). Glycaemia and proangiogenic factors concentrations were measured at rest and immediately after exercise. Results T1D patients' …

Aims To evaluate the efficacy and safety of ipragliflozin in Japanese patients with type 2 diabetes mellitus and inadequate glycemic control and investigate the impact of maintaining exercise habits during treatment. Materials and methods A total of 20 patients were enrolled …

Our objectives were to determine if there are quantitative associations between amounts and intensities of physical activities (PA) on NMR biomarkers and changes in skeletal muscle gene expressions in subjects with high risk for type 2 diabetes (T2D) performing a 3-month PA intervention. We found that PA was associated with beneficial biomarker changes in a factor containing several VLDL and HDL subclasses and lipids in principal component analysis (P=< 0.01). Division of PA into quartiles demonstrated significant changes in NMR …

ABSTRACT Study Objective: Epidemiological studies have shown a close correlation between obesity and sleep disorders which threatens the quality of life in the elderly. Thus, the purpose of this research was to study the effect of the aerobic exercise (with the aim of decreasing obesity) on quality of sleep in obese elderly women. Method: 34 obese elderly women with sleep disorder recognized by Pittsburgh Sleep Quality Index (PSQI), were recruited purposefully from the Preventive healthcare Center and randomly allocated to two …

New Insights in Obesity: Genetics and Beyond … Felipe Monnerat Marino Rosa1,2, Renato Vidal Linhares2,4,6*, José Quaresma2, João Regis Ivar Carneiro2, Valéria Bender Braulio2,5, Roberto Simão1,3, Denise Pires de Carvalho2 and José Fernandes Filho1-3 … 1Programa de Pós Graduação em Educação Física da Universidade Federal do Rio de Janeiro- RJ, Brasil 2Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro-RJ, Brasil 3Escola de Educação Física e Desportos, Universidade Federal do …

Background Achieving weight loss (WL) in a short time regardless of its consequences has always been the focus of many obese and overweight people. In this study, anthropometric and metabolic effects of two diets for rapid and slow WL and their consequences were examined. Methods Forty-two obese and overweight individuals were randomly divided to 2 groups; rapid WL (weight loss of at least 5% in 5 weeks) and slow WL (weight loss of at least 5% in 15 weeks). To compare the effects of the rate of WL in 2 groups, the same amount of …