We aimed to establish jump power cut-offs for the composite outcome of either sarcopenia (EWGSOP2) or dysmobility syndrome using Asian and Caucasian cohorts. Estimated cut-offs were sex specific (women:< 19.0 W/kg; men:< 23.8 W/kg) but not ethnicity specific. Jump power has potential to be used in definitions of poor musculoskeletal health. Purpose Weight-corrected jump power measured during a countermovement jump may be a useful tool to identify individuals with poor musculoskeletal health, but no cut-off values exist. We …

Introduction: In contrast to obesity, little is known about the human lean phenotype associated with gut microbiota composition. Objective: We aimed to investigate whether the bacterial composition of lean athletes with a positive energy balance differs from the equal-calorie food group. Methods: Twenty-four male participants were included in this cross-sectional study: lean athletes with a positive energy balance (LA, n 12) and control group athletes (CTRLs, n 12). Nutritional data, resting and total energy expenditure, and body …

Today, obesity is a health threat in developed and developing countries. The most important disorders caused by weight gain and obesity are fatty liver disease, type 2 diabetes, and kidney failure [1]. In obese people, blood pressure rises to meet the needs of higher metabolism. Increased pressure inside the glomerulus can cause serious damage to the kidneys and increase the risk of chronic kidney disease in a long period. It can also be a risk factor for nephrolithiasis and several kidney malignancies, including kidney cancer [2]. The …

Gait assessment is important for identification of potential faller among the elderly populations. Slope walking is associated with fall risk factor and elderly women have higher fall rate compared with elderly men. Therefore, this study investigated gait characteristics of elderly women in overground and slope walkway conditions. Thirty healthy elderly women (15 younger-elderly women and 15 older-elderly women) walked along the linear walkway including three walking conditions (overground, ascent and descent conditions). Temporal …

PURPOSE: Some athletes consume alcohol prior to training and sports events, possibly because they believe that alcohol may aid in reducing pain and anxiety, increasing confidence, and promoting aggressiveness. While previous studies have shown that alcohol consumption acutely impairs endurance exercise performance, its effects on anaerobic exercise performance have not been well established. Therefore, this study investigated the effect of a small dose of alcohol on anaerobic exercise performance. METHODS: In a …

Hypophosphatasia (HPP) is a rare disorder resulting from biallelic loss-of-function variants or monoallelic dominant negative variants in the ALPL gene. We herein describe the clinical outcome of a 32-year-old woman with childhood-onset HPP caused by compound heterozygous variants in ALPL. Her chief complaints were severe musculoskeletal pain, muscle weakness, and impaired daily activities necessitating assistance in housework and child-rearing in addition to a history of early tooth loss and mildly short stature. Asfotase alfa …

ABSTRACT Background and Objectives: Recent studies have shown the high prevalence of insulin resistance and zinc deficiency among hemodialysis patients. Zinc deficiency can be related to insulin resistance, as zinc is involved in the synthesis, secretion, action, and storage of insulin. This study aimed at evaluating the effect of zinc supplementation on lipid profile, insulin resistance, and as well as body composition in non-diabetic hemodialysis patients. Methods: In this placebo-controlled, double-blind, and randomized trial, 61 non …

Objectives This study aimed to develop an equation model combining physical fitness and anthropometric parameters and compare its results with those of bioelectrical impedance analysis (BIA)-measured lean mass (LM) using dual-energy X-ray absorptiometry (DXA)-measured appendicular muscle mass (AMM) as reference. Design Observational analysis. Setting and Participants Healthy community-dwelling older subjects. Methods A total of 1020 participants were randomly allocated to the development group (development group, n …

Results Median vitamin D level was 14.9 ng/mL. The prevalence of VDD (defined as< 20 ng/ml) was 74.5%. Compared with the highest quartile (Q4, reference), the aORs for VDD across decreasing quartiles (from Q3 to Q1) were 1.05, 1.06, 1.10 for FVC, and 1.07, 1.10, 1.10 for FEV1 (P for trend< 0.01 for both), in all subjects. Similarly, the aOR of having VDD for men also increased with decreasing quartiles of FVC and FEV1 in a dose-response manner (p for trend< 0.01 for both). However, neither FVC nor FEV1 was associated with …

Aim Dyslipidemia (DL) is commonly associated with non‐alcoholic fatty liver disease (NAFLD). Pemafibrate, a selective peroxisome proliferator activated receptor α modulator (SPPARMα), has been shown to improve liver function among patients with DL. The aim of this single‐arm prospective study is to evaluate the efficacy of pemafibrate in NAFLD patients with DL. Methods Twenty NAFLD patients with DL who received pemafibrate (0.1 mg) twice a day for 12 weeks were prospectively enrolled in this study. The primary end …