Introduction Renal hyperfiltration (RHF) has been found to be an independent predictor of adverse cardiovascular outcome. However, it remains uncertain whether it is precursor of chronic kidney disease (CKD) in a healthy population. Materials and methods To determine relative risks and identify the predictor of incident proteinuria and decline of estimated glomerular filtration rate (eGFR) in subjects with RHF. A total of 55,992 subjects aged≥ 20 years who underwent health check-up during 2004–2017 were included. Among them …

Capsinoids are some of the most promising ingredients to increase energy expenditure (EE) due to brown adipose tissue (BAT) activation. However, there is limited information regarding the effect of prolonged capsinoid ingestion (CI) on BAT activity and resting EE (REE) in healthy, middle-aged, normal to overweight subjects (Sub healthy) with distinct BAT characteristics. We examined the changes in BAT density (BAT-d), using near-infrared time-resolved spectroscopy, and REE/kg induced by daily CI. Forty Sub healthy [age, 43.8 (mean) …

Abstract Background & Aims Studies on the relationship between appendicular skeletal muscle mass percentage (ASM%) and non-alcoholic fatty liver disease (NAFLD) has been widely discussed. The aim of this study was to evaluate the relationship between ASM% and NAFLD and determine whether there was any gender difference or not. Method This study included 386 patients with biopsy-proven NAFLD. Multivariable logistic regression analysis and subgroup analysis were applied to determine the association between ASM% and …

Aim To investigate associations between changes in vegetable and fruit (V&F) intakes and anthropometric indices (weight, BMI,% body fat, waist circumference), including differences by sex, during a dietary weight‐loss intervention. Methods Adults (18‐45 years) with overweight/obesity (BMI 25‐35 kg/m2) entered a 10‐week pre‐post study, receiving individualised consults with an Accredited Practising Dietitian targeting increased V&F intakes. Dietary intake was assessed using 24‐hour recalls and food frequency …

Purpose To assess the effect of Nigella sativa (NS) oil supplements on CVD risk factors in a crossover design for the first time. Methods Obese and overweight healthy women were randomized to receive NS oil (2000 mg/day) and placebo. This intervention period lasted for 8 weeks and separated by a 4-week washout period. An iso-caloric diet was given to every individual throughout the study. Blood pressure, lipid profile, atherogenic indices and liver enzymes were measured. Pkcross procedure was performed for statistical analyses using …

Aims Sarcopenia is a serious problem because of its poor prognosis. Growth differentiation factor 15 (GDF15) is associated with mitochondrial dysfunction, inflammation, insulin resistance and oxidative stress, which may play crucial roles for the development of sarcopenia. We aimed to examine whether serum GDF15 level is associated with muscle mass, strength and lower extremity function in older patients with cardiometabolic disease. Methods Serum GDF15 levels were measured in 257 patients with cardiometabolic …

Objective The aim of this study was to investigate the effect of oral vitamin K2 (Menaquinone‐7 [MK‐7]) on clinical and biochemical parameters in polycystic ovary syndrome (PCOS) patients. Methods In this randomized, double‐blind, placebo‐controlled clinical trial, 84 PCOS patients were randomly assigned into the treatment (90 µg Menaquinone‐7 daily for 8 weeks) and placebo groups. Insulin resistance, lipid profile, endocrine biomarkers, and body composition of the participants were measured before and after the intervention. This study …

Okara is a byproduct of soymilk manufacturing and a rich source of protein and dietary fiber. We investigated whether okara intake improves the habit of defecation in young Japanese women (n= 52) with self‐reported constipation. Subjects were categorized into placebo and test groups, who ingested soymilk (0.1 g fiber/meal) and okara (4.1 g fiber/meal) soups, respectively, every day for breakfast, for 2 weeks. Subjects' body composition, bowel movement frequency per week, and constipation assessment scale (CAS) and brief‐type …

Purpose Aging adults from low-income residential areas were found to have poor nutritional status and mental health based on National Health and Morbidity Survey Malaysia (2015). Good nutrient intake contributes positively in averting these problems. Traditional Asian vegetables (ulam) are rich in polyphenols, antioxidants and fibres which could enhance nutritional status and mood state. This study intended to determine the relationship between habitual ulam intake and nutritional status, mood state and cognition among 252 aging …

Aim To compare echocardiographic parameters between female powerlifters, fitness‐oriented athletes, and sedentary controls. Methods A between‐subject, cross‐sectional experimental design was adopted. Echocardiographic parameters were measured in female powerlifters (n= 10; progressive overload 60%–95% of 1 repetition maximum [RM]), fitness‐oriented athletes (n= 10; 50%–70% of 1‐RM), and sedentary control subjects (n= 10). Comparisons were made with Kruskal‐Wallis tests, one‐way analyses of variance, and eta …